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Identification of DS-Associated Markers Using Single-Cell RNA-Seq Analysis
(A) SRCCA from FSTL4, BRN3B, and SNCG were combined for the top 1,000 correlating genes, and 148 genes were found to be commonly expressed between the 3 populations.
(B–D) In addition, SRCCA for FSTL4 was combined with (B) retinal progenitor genes, (C) RPE genes, and (D) photoreceptor genes and demonstrated minimal overlapping expression. n = 3 biological replicates using the H9 cell line.
