FIGURE 2.

Dietary uridine decreases mean intestinal tumor number in Apc^Min/+ mice fed an AIN-93G diet. Values are total tumor numbers in the small intestine and colon ± SEMs, n = 9–11/group. Data were analyzed by using a Student's t test with a Bonferroni correction for multiple comparisons. (A) Mice were weaned onto a nucleoside-containing folate-deficient AIN-93G (0.6% uridine, 11 mice; 0.2% thymidine, 10 mice; 0.1% deoxyuridine, 9 mice) or FD control (10 mice) diet at 3 wk of age and consumed the diets until being killed at 17 wk of age. (B) Mice were weaned onto a uridine-supplemented folate-deficient AIN-93G (0.1% uridine, 12 mice; 0.01% uridine, 10 mice; 0.001% uridine, 11 mice) or FD control (9 mice) diet at 3 wk of age and consumed the diets until being killed at 17 wk of age. Apc^Min/+, mouse model lacking one copy of the APC gene; dU, deoxyuridine; FD, folate-deficient; T, thymidine; U, uridine.