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. 2018 Mar 13;2(5):nzy013. doi: 10.1093/cdn/nzy013

FIGURE 3.

FIGURE 3

Dietary uridine affects mean intestinal tumor burden in ApcMin/+ mice fed an AIN-93G diet. Values are total tumor burden in the small intestine ± SDs, n = 9–11/group. Data were analyzed by using a Student's t test with a Bonferroni correction for multiple comparisons. (A) Mice were weaned onto a nucleoside-containing folate-deficient AIN-93G (0.6% uridine, 11 mice; 0.2% thymidine, 10 mice; 0.1% deoxyuridine, 9 mice) or FD control (10 mice) diet at 3 wk of age and consumed the diets until being killed at 17 wk of age. (B) Mice were weaned onto a uridine-supplemented folate-deficient AIN-93G (0.1% uridine, 12 mice; 0.01% uridine, 10 mice; 0.001% uridine, 11 mice) or FD control diet (9 mice) at 3 wk of age and consumed the diets until being killed at 17 wk of age. ApcMin/+, mouse model lacking one copy of the APC gene; dU, deoxyuridine; FD, folate-deficient; T, thymidine; U, uridine.