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. 2018 May;13(5):896–907. doi: 10.4103/1673-5374.232488

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Copyright: © 2018 Neural Regeneration Research

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NgR homologs within spinal cord and microglial/macrophage cell lysates.

(A) NgR protein expression was detected in spinal cord and isolated microglial/macrophage cell lysates from ngr1^+/+ and ngr1^–/– mice. (B) Expression of NgR2 and NgR3 in microglial/macrophage cell lysates during EAE progression as well as spinal cord lysates from naïve ngr1^+/+ and ngr1^–/– mice. (C) Immunofluorescent co-labeling of either CD11b- or Iba1-positive microglial/macrophage cells, with the NgR3, present in spinal cord inflammatory lesions of ngr1^+/+ mice at the chronic stage of EAE (i.e., clinical score 3). NgR2: Nogo66 receptor homolog 1; NgR3: Nogo66 receptor homolog 2; Iba1: ionizing binding adaptor molecule 1.