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. 2018 Mar 8;10(4):1340–1354. doi: 10.1016/j.stemcr.2018.02.002

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© 2018 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

JMJD1A and JMJD1B Substantially Contribute to H3K9 Demethylation in ESCs

(A) Time-course analysis of JMJD1B-depletion-induced increase in H3K9me2 in 4OHT-treated Quad-cKO cells.

(B) Immunoblot analyses of H3K9 methylation levels in the indicated ESC lines.

(C) The methylation levels of H3K9me1 (left), H3K9me2 (middle), and H3K9me3 (right) in the indicated ESC lines were determined by immunoblot analysis. The intensities of H3K9me signals of wild-type cells were defined as 1. Data are presented as means ± SD (n = 3 independent experiments). ^∗∗p < 0.01; ^∗∗∗p < 0.001 (Student's t test).

(D–F) Nuclear distribution profiles of H3K9me1 (D), H3K9me2 (E), and H3K9me3 (F) in JMJD1A/JMJD1B-depleted ESCs compared with those in the wild-type ESCs. Scale bars, 5 μm.