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. 2018 Jun 6;9:1203. doi: 10.3389/fmicb.2018.01203

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Copyright © 2018 Maia, de Barros, de Oliveira, Cardoso, dos Santos, Pieri, Ramalho, da Cunha and Moreira.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Isobolograms of the synergistic interaction between antimicrobials and bioactive substances for Streptococcus uberis. EC₅₀ = effective concentration of bioactive compound that leading to the twofold reduction of antibiotic’s MIC. Dotted line FICI = 1. (A) Synergistic interaction between 7-EPI and AMP. (B) Synergistic interaction between 7-EPI and GEN. (C) Synergistic interaction between GUT-A and AMP. (D) Synergistic interaction between GUT-A and GEN.