TABLE 2.
Genes Differentially Expressed Between Proximal and Distal Nontumor Tissue at <0.01 Level in Both Groups A and B
| Distal | Proximal | Fold change | Group A | Group B | |
|---|---|---|---|---|---|
|
| |||||
| Gene name | Average RPKM expression | (Proximal/distal) | P-Value | ||
| SLC13A2 | 0.19 | 0.47 | 2.44 | 5.15E-03 | 1.49E-04 |
| NR1H4 | 0.36 | 0.08 | 0.23 | 8.33E-04 | 4.30E-04 |
| SLC9A3 | 8.11 | 1.17 | 0.14 | 3.62E-05 | 1.18E-05 |
| NXPE1 | 5.14 | 9.22 | 1.79 | 2.70E-03 | 6.78E-03 |
| WFDC2 | 0.24 | 1.30 | 5.32 | 9.38E-07 | 1.24E-05 |
| HOXA13 | 0.46 | 0.73 | 1.57 | 2.70E-03 | 1.08E-03 |
| AK1 | 0.37 | 1.99 | 5.33 | 2.36E-07 | 4.12E-06 |
| CYP2C18 | 0.99 | 0.29 | 0.30 | 6.77E-06 | 4.68E-03 |
| ST3GAL4 | 0.36 | 1.18 | 3.27 | 1.58E-07 | 8.61E-05 |
| APOA4 | 0.21 | 0.00 | 0.00 | 7.30E-03 | 3.53E-03 |
| GCG | 0.08 | 0.30 | 3.91 | 6.67E-04 | 2.62E-03 |
| MUC5B | 2.37 | 5.54 | 2.34 | 1.45E-04 | 7.10E-04 |
| TRPM6 | 0.71 | 1.39 | 1.95 | 8.66E-04 | 2.57E-03 |
| PI3 | 0.93 | 2.37 | 2.56 | 1.17E-04 | 1.18E-03 |
| SLPI | 0.92 | 2.20 | 2.39 | 3.90E-03 | 4.56E-03 |
| FOXA2 | 0.38 | 0.89 | 2.34 | 1.50E-04 | 2.71E-03 |
| HOXD13 | 0.01 | 0.22 | 16.00 | 5.42E-04 | 9.49E-05 |
| PYY | 0.36 | 1.27 | 3.54 | 7.00E-04 | 8.74E-05 |
| SLC14A2 | 0.24 | 0.02 | 0.07 | 1.24E-04 | 9.17E-04 |
| SPINK5 | 0.15 | 0.45 | 3.01 | 2.70E-03 | 3.94E-03 |
| CA1 | 1.43 | 2.77 | 1.94 | 7.81E-03 | 6.77E-03 |
| SLC37A2 | 2.42 | 0.30 | 0.12 | 1.98E-03 | 1.35E-03 |
| CHST5 | 0.66 | 2.15 | 3.26 | 1.81E-06 | 2.04E-04 |
| GALNT5 | 0.79 | 1.40 | 1.78 | 2.78E-03 | 6.78E-03 |
| SLC28A2 | 0.30 | 0.69 | 2.31 | 3.73E-03 | 2.29E-03 |
| SLC20A1 | 4.51 | 1.68 | 0.37 | 7.20E-03 | 7.00E-03 |
| AHSG | 0.03 | 0.00 | 0.05 | 5.51E-03 | 1.83E-03 |
| CDHR1 | 1.34 | 3.51 | 2.62 | 1.88E-04 | 4.82E-05 |
| ADRA2A | 0.67 | 0.21 | 0.32 | 1.12E-03 | 5.65E-03 |
| SPON1 | 0.82 | 1.63 | 1.99 | 7.20E-03 | 5.06E-03 |
| CLDN8 | 0.15 | 0.97 | 6.60 | 3.74E-07 | 5.27E-07 |
| HKDC1 | 0.49 | 0.17 | 0.36 | 6.36E-03 | 3.49E-03 |
| B3GNT7 | 2.22 | 9.88 | 4.45 | 4.69E-08 | 5.89E-06 |
| LRRC43 | 0.04 | 0.01 | 0.17 | 8.14E-03 | 3.36E-03 |
| PRAC1 | 0.07 | 1.72 | 24.45 | 5.35E-12 | 2.34E-09 |
| HOXB13 | 0.12 | 2.02 | 16.61 | 3.59E-12 | 7.24E-10 |
| ST6GALNAC6 | 1.23 | 6.55 | 5.33 | 6.82E-10 | 6.84E-06 |
| NLRP4 | 0.02 | 0.01 | 0.25 | 6.67E-03 | 1.43E-03 |
| CYP11B1 | 0.03 | 0.01 | 0.20 | 2.37E-03 | 5.83E-03 |
| NPHS1 | 0.05 | 0.01 | 0.19 | 1.06E-03 | 3.19E-03 |
| CAPN13 | 0.37 | 0.85 | 2.27 | 2.82E-03 | 7.06E-04 |
| PITX2 | 0.35 | 0.02 | 0.07 | 2.02E-06 | 5.09E-11 |
| C7orf57 | 0.03 | 0.01 | 0.33 | 7.88E-03 | 9.02E-04 |
| CPA6 | 0.13 | 0.31 | 2.40 | 6.58E-03 | 2.14E-03 |
| CYP2C19 | 0.56 | 0.15 | 0.26 | 3.23E-06 | 3.77E-03 |
| CKB | 4.04 | 10.24 | 2.54 | 7.63E-05 | 2.16E-03 |
| ANPEP | 10.21 | 1.44 | 0.14 | 8.51E-06 | 9.42E-05 |
| B4GALNT2 | 2.02 | 0.58 | 0.29 | 8.72E-03 | 1.06E-04 |
| DPCR1 | 0.03 | 0.01 | 0.18 | 6.73E-03 | 7.22E-03 |
| DRD5 | 0.11 | 0.01 | 0.07 | 1.60E-03 | 7.10E-05 |
| PKHD1 | 0.07 | 0.02 | 0.27 | 1.00E-04 | 2.53E-04 |
| KRT15 | 0.14 | 0.38 | 2.76 | 6.18E-04 | 8.74E-04 |
| REG3A | 0.70 | 0.16 | 0.23 | 1.78E-04 | 8.93E-04 |
| INSL5 | 0.01 | 0.23 | 15.53 | 5.79E-03 | 3.26E-04 |
| HOXC5 | 0.05 | 0.01 | 0.29 | 9.21E-05 | 1.72E-03 |
| MFSD4 | 0.32 | 1.03 | 3.20 | 1.98E-06 | 3.55E-04 |
| C2orf73 | 0.02 | 0.01 | 0.37 | 4.32E-03 | 5.08E-03 |
| ARSJ | 0.14 | 0.39 | 2.77 | 2.89E-04 | 2.92E-04 |
| B3GALT5 | 0.91 | 3.35 | 3.68 | 6.30E-06 | 1.45E-04 |
| FAM3B | 0.33 | 0.01 | 0.03 | 3.49E-09 | 8.33E-05 |
| C21orf88 | 0.06 | 0.72 | 12.60 | 3.43E-10 | 7.80E-07 |
| FFAR4 | 0.25 | 0.66 | 2.63 | 3.30E-04 | 8.45E-03 |
| GLDN | 0.04 | 0.27 | 7.21 | 9.51E-05 | 1.97E-05 |
| LHFPL3 | 0.70 | 0.21 | 0.30 | 8.75E-04 | 1.49E-05 |
| TMEM72 | 0.21 | 0.42 | 2.02 | 4.12E-03 | 3.59E-03 |
| NWD1 | 0.05 | 0.09 | 1.98 | 8.24E-03 | 3.55E-03 |
| WNT7B | 0.03 | 0.00 | 0.08 | 8.01E-03 | 3.75E-03 |
| CTD-2228K2.5 | 8.24 | 1.56 | 0.19 | 5.23E-04 | 6.05E-05 |
| PLA2G2A | 4.51 | 13.72 | 3.04 | 3.00E-04 | 1.58E-04 |
| ESRRG | 0.07 | 0.02 | 0.28 | 3.98E-05 | 2.96E-03 |
| SULT1C2 | 0.27 | 0.31 | 1.14 | 3.96E-03 | 7.68E-03 |
| HSD3B2 | 0.23 | 0.04 | 0.18 | 7.71E-03 | 9.82E-05 |
| NPY4R | 0.64 | 1.58 | 2.46 | 3.85E-03 | 3.05E-03 |
| MUC12 | 4.82 | 16.21 | 3.37 | 9.48E-07 | 6.61E-05 |
| GBP7 | 0.05 | 0.01 | 0.15 | 4.57E-03 | 5.48E-03 |
| PRAC2 | 0.10 | 0.93 | 9.34 | 3.52E-09 | 1.13E-09 |
| L1TD1 | 0.95 | 0.34 | 0.35 | 8.35E-03 | 7.94E-04 |