Figure 5.
Validation of Predicted Synergistic Interactions. (A) Predicted combinations between cryptagens from the Microsource Spectrum collection. Compound abbreviations are provided in the Supplemental Information. (B) Novel predicted synergistic combinations of cyclosporine, fenbendazole and camptothecin with synthetic Maybridge compounds. (C) Specific interactions between structurally diverse compounds camptothecin (Cam), cyclosporine (Cic), SEW 06533 and SP 01215. (D) De novo predicted synergistic pairs from the ChemDiv Kinase library. Assays were carried out in 8×8 matrices in a pdr1Δpdr3Δ yeast drug pump deficient strain at 0, 1, 2, 4, 8, 16, 32 and 64 µM for each compound. Data are provided in Table S8.