FIG. 6.

Delayed infusion of 10 μg/day of insulin-like growth factor-1 (IGF-1) increased hippocampal immature neuron density 1 week after controlled cortical impact (CCI). (A) Compared to CCI + Veh mice, CCI + IGF-1 mice showed increased doublecortin (DCX; green) immunoreactivity. Scale bar represents 100 μm. (B) Infusion of IGF-1 post-CCI resulted in significantly increased immature neuron density at 7 days post-injury, compared to vehicle treatment (^#p < 0.05). Data are presented as mean + SEM (n = 3 CCI + Veh and n = 5 CCI + IGF-1). SEM, standard error of the mean. Color image is available online at www.liebertpub.com/neu