Table 1.
Biochemical parameters of plasma in Wistar and OXYS rats treated chronically with CEF
| Biochemical parameters | Wistar | OXYS | ||
|---|---|---|---|---|
| Control (saline) | CEF (100 mg/kg/day, 36 days) | Control (saline) | CEF (100 mg/kg/day, 36 days) | |
| Uric acid (mmol/L) | 7.48 ± 0.41 | 7.56 ± 0.26 | 7.70 ± 0.18 | 8.19 ± 0.42 |
| Creatinine (µmol/L) | 59.21 ± 0.44 | 57.70 ± 1.04 | 60.55 ± 0.71 | 58.74 ± 0.93 |
| ALT, U/L | 72.33 ± 4.03 | 70.56 ± 4.72 | 79.14 ± 2.58 | 64.00 ± 1.77$ |
| AST, U/L | 132.66 ± 3.34 | 137.64 ± 6.01 | 187.13 ± 15.04***,### | 148.72 ± 4.51$$ |
| Total bilirubin (µmol/L) | 2.38 ± 0.21 | 1.99 ± 0.31 | 2.10 ± 0.21 | 1.79 ± 0.24 |
| Ca2+ (mmol/L) | 2.78 ± 0.03 | 2.70 ± 0.04 | 2.68 ± 0.03 | 2.59 ± 0.06** |
| Phosphate (mmol/L) | 2.49 ± 0.06 | 2.46 ± 0.10 | 2.58 ± 0.17 | 2.30 ± 0.06 |
| Total cholesterol (mmol/L) | 1.82 ± 0.06 | 1.74 ± 0.14 | 1.42 ± 0.14*,# | 1.56 ± 0.05 |
| Triglycerides, g/L | 1.07 ± 0.17 | 1.14 ± 0.12 | 1.30 ± 0.10 | 1.59 ± 0.15*,# |
| LDL-C (µmol/L) | 0.463 ± 0.075 | 0.495 ± 0.089 | 0.213 ± 0.079*,# | 0.200 ± 0.031*,## |
| HDL (mmol/L) | 0.869 ± 0.042 | 0.843 ± 0.066 | 0.704 ± 0.060* | 0.774 ± 0.045 |
Data are presented as the Mean ± S.E.M. of the values obtained in an independent group of animals (n = 7–8 per group)
Statistically significant differences: *P < 0.05, ***P < 0.001 versus “Wistar + saline” group; #P < 0.05, ##P < 0.01, ###P < 0.001 versus “Wistar + CEF” group; $P < 0.05, $$P < 0.01 versus “OXYS + saline” group