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. 2018 Apr 24;12(Suppl 4):43. doi: 10.1186/s12918-018-0561-2

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© The Author(s) 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License(http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Schematic diagram of leukemogenesis and haematopoietic stem cell lineages. Upper row: haematopoietic linage. Lower row: leukaemia linage. The flat-head arrows extending from terminally differentiated cell (D) with red color indicates feedback inhibition to self-renewal of S and A (colour online)