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. 2018 Apr 24;12(Suppl 4):43. doi: 10.1186/s12918-018-0561-2

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© The Author(s) 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License(http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Bifurcation diagram in the parameter space of g₁ and g₂. When g₁<0.115 or g₂<0.152, they could co-compensate the inefficiency of each other in order to maintain in the state of health. However, when g₁>0.115 or g₂>0.152, they induce a state transition, that is, a stable composite state appear. The dynamics of the system can be divided into two classes: (I) healthy steady state and (II) the coexisting steady state of the healthy and leukaemia species (colour online)