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. 2018 Apr 18;28(7):2594–2609. doi: 10.1093/cercor/bhy084

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© The Author(s) 2018. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 2. — T-type calcium channels mediate burst firing in mature granule cells. Burst firing was impaired by bath application of different T-type channel blockers: Mibefradil, TTA-A2 and NNC-55 0396. These blockers, similarly to nickel, profoundly affected the first ISI, with no significant modification of the tonic spikes (fourth ISI). Insets show representative examples of electrophysiological traces in the corresponding groups. Scale bars: 10 mV/100 ms. **,***P < 0.01, P < 0.001 Mann–Whitney U-test.