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. 2018 Feb 2;32(7):3487–3501. doi: 10.1096/fj.201700217R

Figure 7.

Figure 7

A2AR activation modifies RANKL/OPG secretion from osteoblast. A) RANKL, OPG, osteocalcin, Runx2, and osteonectin mRNA fold change in murine osteoblast precursors after 24 h challenge with osteogenic medium in the presence of CGS21680, alone or with ZM241385, compared with control (n = 4). B) RANKL and OPG mRNA fold change in murine osteoblast precursors after 24 h challenge with osteogenic medium in the presence of CGS21680, alone or with ZM241385, and in combination with Sema3A compared with control (n = 4). ***P < 0.001, **P < 0.01, *P > 0.05 (ANOVA).