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. 2018 Feb 27;32(7):3844–3858. doi: 10.1096/fj.201701378RR

Figure 6.

Figure 6

ADF affects major metabolic transcriptional pathways in soleus muscle. A) Heat map of significant GO pathways in soleus tissue. ADF and EXADF prominently enhanced expression of genes involved in fatty acid metabolism and mitochondrial activity while down-regulating genes involved in lipid synthesis and glycolysis. B–D) Volcano plots of GO pathways in soleus muscle of ADF, EX, and EXADF animals vs. CTRL. E–H) PPAR-α, hormone-sensitive lipase, ACADL, and PDK4 mRNA levels analyzed by qPCR, normalized to actin, and displayed as relative fold change compared to CTRL group. Values are means ± sem (n = 7 CTRL, n = 8 ADF, n = 9 EX, and n = 8 EXADF mice). *P < 0.05, **P < 0.01, ***P < 0.001.