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. 2018 Feb 26;32(7):3752–3764. doi: 10.1096/fj.201700667R

Figure 3.

Figure 3

Inhibition of FGF23 signaling induces Epo secretion in Nx mice. A) Serum Epo concentrations measured by ELISA in sham-treated and 5/6 Nx mice untreated (vehicle-treated) or treated with FGF23 blocking peptide or Epo (sham, n = 11; Nx, n = 10). Samples were measured in duplicate. B–G) qPCR in sham-treated and 5/6 Nx mice untreated or treated with FGF23 blocking peptide or Epo. Data are represented as fold change (Δ) relative to Hprt. Renal mRNA expression of Epo (B), Hif1α (C), and Hif2α (D) (sham, n = 15; Nx, n = 13); BM mRNA expression of Epo (E), Hif1α (F), and Hif2α (G) (sham, n = 14; Nx, n = 13). Data are represented as means ± sem. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.