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. 2018 Apr 18;28(7):2577–2593. doi: 10.1093/cercor/bhy082

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© The Author(s) 2018. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Interneurons tangential migration to the cortex is impeded at late but not mid phases of development in the Vegfa^120/120 mutant forebrain with a defective vascular network. (A) IB4⁺ labeling of blood vessels in coronal sections of E14.5 Vegfa^+/+ wildtype and Vegfa^120/120 knock-in mouse forebrain; with vessel diameter, number and area fraction occupancy quantified in bar charts. (***P ≤ 0.0001, t-test; n = 4 for each). (B) IB4⁺ labeling of blood vessels and immunolocalization of Calbindin⁺ interneurons in coronal sections of E14.5 Vegfa^+/+ wildtype and Vegfa^120/120 knock-in mouse forebrain, with mean number of interneurons represented in bar charts. (*P ≤ 0.05; t-test; n = 3 for each). (C) IB4⁺ labeling of blood vessels and immunolocalization of Calbindin⁺ interneurons in the coronal sections through the subpallium of E18.5 VegfA^+/+ and VegfA^120/120 mouse forebrains. Arrows show accumulation of interneurons adjacent to dilated blood vessels. (Data in all graphs represent values ±SEM). (D) Mean number of Calbindin⁺ cells quantified in subpallial regions shown by bar charts. LGE, lateral ganglionic eminence; Cx, cortex; CP, cortical plate; SP, subplate; IZ, intermediate zone; IZ/SVZ, lower intermediate zone/subventricular zone; VZ, ventricular zone.