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. 2018 Apr 18;28(7):2577–2593. doi: 10.1093/cercor/bhy082

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© The Author(s) 2018. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Decreased cortical interneuron numbers and alterations in their intracortical distribution in Tie2Cre;Vegfa^fl/fl mutant forebrains. (A) In situ hybridization for the Gad67 and Lhx6 mRNA in the cortex of E13.5 Vegfa^fl/fl control (gray) and Tie2Cre;Vegfa^fl/fl mutant (black) and their (B) quantifications in cortical regions (Student’s t-test; n = 4 when combining n = 2 at E13.5 combined with n = 2 E14.5; *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001). (C) Graphs show mean total numbers and percentages of PH3⁺ proliferating MGE progenitors in the E13.5/E14.5 Vegfa^fl/fl control and Tie2Cre;Vegfa^fl/fl mutant animals (Student’s unpaired t-test, n = 4 when combining n = 2 at E13.5 combined with n = 2 E14.5; *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001). (D) Immunolabelling of Calbindin+ and Reelin+ cells and IB4⁺ blood vessels, in the cortex of E17.5 Vegfa^fl/fl and Tie2Cre;Vegfa^fl/fl mutant mice with (E) their total numbers and intracortical distributions represented graphically. (Student’s unpaired t-test, n = 3 for each; *P ≤ 0.05, **P ≤ 0.01) (Graphs show mean values ±SEM).