Figure 4.
Dose-dependent neuroprotective effect on neurological score. Rats underwent neurological scoring just prior to reperfusion (T 1h30) and 48 h post-MCAo (T 49h30). Figures show (a) the combined neurological score in the vehicle control group (n = 13) and (S)-roscovitine treatment groups: 0.1 mg/kg/h (n = 10) and 1 mg/kg/h (n = 13). Data are expressed as median and interquartile ranges. Data were analyzed by Wilcoxon matched-pairs test. Sign indicate value different from T 1h30: * p < 0.05. Figure (b) shows a significant positive correlation between recovery and the effective delivered dose. Pearson’s correlation coefficient: r = 0.332, r2 = 0.110, p = 0.048.