Change in extradural temperature, esophageal temperature, and carotid
artery blood flow before, during, and after 30 min of global
cerebral ischemia (time 0) in near-term fetal sheep, showing the
ischemia-normothermia (n = 8), ischemia-48 h hypothermia (n = 8),
and ischemia-72 h hypothermia (n = 8) groups. Extradural temperature
was significantly reduced in both hypothermia groups during
treatment (p < 0.05) and returned to baseline when cooling ended
at 48 or 72 h. A significant reduction in esophageal temperature was
seen with the onset of hypothermia (p < 0.05). CaBF increased in
the ischemia-normothermia group between 6 and 36 h after ischemia
compared to either hypothermia group (p < 0.05). Data are
mean ± SEM, *p < 0.05 ischemia-72 h hypothermia vs.
ischemia-normothermia, #p < 0.05 ischemia-48 h
hypothermia vs. ischemia-normothermia.