Table 1.
Baseline | 2 h | 4 h | 6 h | 1 day | 2 days | 7 days | |
---|---|---|---|---|---|---|---|
pH | |||||||
Normothermia | 7.38 ± 0.01 | 7.36 ± 0.01 | 7.38 ± 0.01 | 7.39 ± 0.01 | 7.35 ± 0.02 | 7.39 ± 0.01 | 7.44 ± 0.01 |
48 h hypo | 7.37 ± 0.01 | 7.34 ± 0.01 | 7.37 ± 0.01 | 7.38 ± 0.01 | 7.37 ± 0.01 | 7.38 ± 0.01 | 7.32 ± 0.01 |
72 h hypo | 7.38 ± 0.01 | 7.37 ± 0.01 | 7.38 ± 0.01 | 7.41 ± 0.01 | 7.40 ± 0.01 | 7.41 ± 0.01 | 7.37 ± 0.01 |
PaCO2 (mmHg) | |||||||
Normothermia | 48.1 ± 1.0 | 49.1 ± 1.2 | 48.6 ± 1.4 | 48.6 ± 1.4 | 50.7 ± 1.7 | 50.1 ± 0.9 | 53.9 ± 0.6 |
48 h hypo | 48.9 ± 1.3 | 47.5 ± 1.3 | 46.3 ± 0.8 | 47.4 ± 1.2 | 45.1 ± 1.4 | 46.8 ± 1.0 | 51.9 ± 1.4 |
72 h hypo | 50.9 ± 0.6 | 49.5 ± 1.4 | 47.5 ± 1.3 | 47.5 ± 1.2 | 50.8 ± 1.3 | 49.6 ± 1.2 | 52.9 ± 1.4 |
PaO2 (mmHg) | |||||||
Normothermia | 20.9 ± 1.5 | 20.8 ± 1.3 | 21.4 ± 1.6 | 20.0 ± 1.6 | 18.8 ± 1.5 | 21.2 ± 1.7 | 20.5 ± 1.5 |
48 h hypo | 21.8 ± 1.0 | 21.3 ± 1.3 | 20.6 ± 1.7 | 20.1 ± 1.5 | 21.0 ± 1.4 | 20.0 ± 2.0 | 22.3 ± 1.6 |
72 h hypo | 22.3 ± 0.9 | 23.1 ± 0.7 | 22.4 ± 1.1 | 22.0 ± 1.0 | 21.0 ± 1.5 | 22.1 ± 1.1 | 21.3 ± 0.8 |
Lactate (mmol/L) | |||||||
Normothermia | 1.3 ± 0.1 | 3.6 ± 0.6* | 2.9 ± 0.5 | 2.4 ± 0.4 | 3.9 ± 0.9* | 2.1 ± 0.6 | 1.4 ± 0.2 |
48 h hypo | 1.2 ± 0.0 | 2.9 ± 0.4* | 3.1 ± 0.5* | 2.5 ± 0.4* | 2.3 ± 0.4 | 2.6 ± 0.4* | 1.0 ± 0.1 |
72 h hypo | 1.1 ± 0.1 | 2.5 ± 0.4* | 2.5 ± 0.3* | 2.0 ± 0.3 | 1.8 ± 0.4 | 1.5 ± 0.3 | 1.0 ± 0.1 |
Glucose (mmol/L) | |||||||
Normothermia | 0.9 ± 0.0 | 1.3 ± 0.1* | 1.2 ± 0.1* | 1.2 ± 0.1* | 1.4 ± 0.1* | 1.2 ± 0.1 | 0.9 ± 0.1 |
48 h hypo | 0.8 ± 0.0 | 1.2 ± 0.1* | 1.3 ± 0.1* | 1.3 ± 0.1* | 1.1 ± 0.1 | 1.3 ± 0.1* | 0.7 ± 0.1 |
72 h hypo | 1.0 ± 0.0 | 1.4 ± 0.1* | 1.5 ± 0.1* | 1.4 ± 0.1* | 1.4 ± 0.1* | 1.3 ± 0.1 | 0.9 ± 0.1 |
Normothermia: ischemia-normothermia (n = 8); 48 h hypo: ischemia-48 h hypothermia (n = 8); 72 h hypo: ischemia-72 h hypothermia (n = 8).
p < 0.05 vs. baseline.