Table 4. Summary of PBZ effects on human tumor cell culture proliferation at two concentrations of FCS.
Phenoxybenzamine | Test/Control (%) at Drug Concentration [uM] | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cell Line | Study No. | ECS | Exp No | 1,0E-03 | 3,2E-03 | 1,0E-02 | 3,2E-02 | 1,0E-01 | 3,2E-01 | 1,0E+00 | 3,2E+00 | 1,0E+01 | 3,2E+01 | 1,0E+02 |
CNXF U-251 | P495A | 10% | QA1489-P1456245-5 | - | 85 | 90 | 93 | 90 | 93 | 92 | 94 | 103 | 118 | 98 |
- | - | - | - | - | - | - | - | - | - | - | - | - | - | |
P495C | 1% | RA0214-P1537009-4 | - | - | - | - | - | - | 98 | 102 | 102 | 98 | 36 | |
LXFA NCI-H522 | P495A | 10% | QA1490-P1456251-5 | - | 76 | 81 | 82 | 96 | 98 | 99 | 107 | 108 | 110 | 14 |
P495B | 10% | QA1971 | 100 | - | 100 | - | 100 | - | 100 | 100 | 93 | 97 | 29 | |
P495C | 1% | RA0214-P1537009-5 | - | - | - | - | - | - | 99 | 106 | 99 | 89 | 6 | |
LXFS DMS273 | P495A | 10% | QA1489-P1456245-6 | - | 83 | 75 | 74 | 81 | 80 | 76 | 87 | 82 | 100 | 105 |
- | - | - | - | - | - | - | - | - | - | - | - | - | - | |
P495C | 1% | RA0215-P1536458-4 | - | - | - | - | - | - | 104 | 101 | 91 | 100 | 49 | |
LYXF SU-DHL-1 | P495A | - | - | - | - | - | - | - | - | - | - | - | - | |
P495B | 10% | QA1976 | 100 | - | 100 | - | 100 | - | 98 | 100 | 100 | 94 | 0 | |
P495C | 1% | RA0218-P1537021-4 | - | - | - | - | - | - | 97 | 96 | 91 | 45 | 7 | |
MAX T47D | P495A | 10% | QA1491-P1456274-4 | - | 97 | 92 | 92 | 97 | 97 | 101 | 102 | 97 | 95 | 74 |
P495B | 10% | QA1975 | 94 | - | 93 | - | 92 | - | 80 | 79 | 79 | 84 | 57 | |
P495C | 1% | RA0215-P1536458-5 | - | - | - | - | - | - | 98 | 99 | 96 | 92 | 37 | |
MEXF UACC-257 | P495A | 10% | QA1489-P1456245-7 | - | 103 | 101 | 113 | 101 | 104 | 101 | 109 | 107 | 106 | 68 |
- | - | - | - | - | - | - | - | - | - | - | - | - | - | |
P495C | 1% | RA0216-P1535660-4 | - | - | - | - | - | - | 101 | 106 | 107 | 77 | 41 | |
MMX RPMI8226 | P495A | 10% | QA1491-P1456274-5 | - | 86 | 80 | 76 | 83 | 84 | 89 | 87 | 98 | 99 | 10 |
P495B | 10% | QA1974 | 100 | - | 100 | - | 100 | - | 88 | 92 | 94 | 95 | 16 | |
P495C | 1% | RA0218-P1537021-5 | - | - | - | - | - | - | 102 | 101 | 95 | 77 | 5 | |
OVXF OVCAR-8 | P495A | 10% | QA1490-P1456251-6 | - | 84 | 90 | 86 | 85 | 86 | 84 | 92 | 90 | 96 | 67 |
P495B | 10% | QA1972 | 92 | - | 90 | - | 86 | - | 89 | 84 | 82 | 74 | 32 | |
P495C | 1% | RA0216-P1535660-5 | - | - | - | - | - | - | 102 | 104 | 100 | 61 | 22 | |
PRXF PC-3 | P495A | 10% | QA1490-P1456251-7 | - | 91 | 83 | 87 | 87 | 91 | 86 | 89 | 86 | 82 | 52 |
P495B | 10% | QA1973 | 81 | - | 88 | - | 84 | - | 89 | 92 | 77 | 74 | 49 | |
P495C | 1% | RA0217-P1537015-3 | - | - | - | - | - | - | 102 | 105 | 100 | 58 | 22 |