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. 2018 Jun 13;13(6):e0198645. doi: 10.1371/journal.pone.0198645

Fig 1. The work flow of creating directed networks.

Fig 1

A: Schematic of the Multiple Sequence Alignment and impact calculation B: Example of the impact analysis of one of the amino acids of DHFR performed on 2303 sequences obtained from Pfam database [24] (Pfam Id: PF00186) using PDB id 3QL3 as a reference. The green and blue lines drawn at 0.7 and 0.8 represent the two cut-offs. Amino acid 27 impacts no amino acids with γ = 0.8 and 3 at γ = 0.7. The data point at (1,1) is the identity relation showing the dependence of 27 on itself. It is not used in the analyses. C: Partial network that was constructed for the impact of amino acid 27 and γ = 0.7.