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. 2018 Mar 20;170(2):257–270. doi: 10.1007/s10549-018-4757-3

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 3 — Receiver-operating characteristic (ROC) curves for the plasma and serum 4-miRNA panels for discriminating BC patients from HCs. AUC: area under the curve. a Combined two cohorts from the training and testing phases (A1: plasma from 170 BC patients and 170 HCs; A2: Serum from 174 BC patients and 172 HCs); b Training phase (B1: plasma from 24 BC patients and 24 HCs; B2: Serum from 24 BC patients and 24 HCs); c Testing phase (C1: plasma from 146 BC patients and 146 HCs; C2: Serum from 150 BC patients and 148 HCs); d External validation phase (D1: plasma from 30 BC patients and 30 HCs; D2: Serum from 30 BC patients and 30 HCs)