Table 3.
Factors associated with current and lifetime disorders
| Predictor | Step 1 | Step 2 | Step 3 | Mediation analysisa | |||
|---|---|---|---|---|---|---|---|
| Odds ratio | 95% confidence interval | Odds ratio | 95% confidence interval | Odds ratio | 95% confidence interval | Bootstrapped 95% confidence interval | |
| Lifetime depression disorders | |||||||
| Sexual abuse | 5.60 | 1.95–16.04 | 3.37 | 1.08–10.54 | |||
| CpG5/6 | 1.14 | 1.05–1.24 | 1.10 | 1.01–1.21 | |||
| χ2(1, N = 75) = 15.30, p < 0.001 | – | ||||||
| Current depression disorders | |||||||
| Sexual abuse | 5.60 | 1.95–16.04 | 1.20 | 0.38–3.80 | |||
| CpG2/3 | 1.11 | 1.03–1.20 | 1,11 | 1.02–1.20 | |||
| χ2(1, N = 75) = 8.77, p = 0.012 | 0.13–1.33 | ||||||
| Sexual abuse | 5.60 | 1.95–16.04 | 1.38 | 0.44–4.26 | |||
| CpG4 | 1.11 | 1.02–1.21 | 1.10 | 1.00–1.21 | |||
| χ2(1, N = 75) = 6.05, p = 0.049 | 1.33–1.42 | ||||||
| Sexual abuse | 5.60 | 1.95–16.04 | 1.01 | 0.30–3.35 | |||
| CpG5/6 | 1.14 | 1.04–1.25 | 1.14 | 1.04–1.26 | |||
| χ2(1, N = 75) = 9.96, p = 0.007 | 0.16–2.01 | ||||||
| Sexual abuse | 5.60 | 1.95–16.04 | 1.40 | 0.46–4.29 | |||
| CpG7/8 | 1.11 | 1.02–1.20 | 1.10 | 1.01–1.19 | |||
| χ2(1, N = 75) = 7.10, p = 0.029 | 0.04–1.22 | ||||||
| Sexual abuse | 5.60 | 1.95–16.04 | 1.02 | 0.31–3.39 | |||
| Exon 1 | 1.16 | 1.05–1.28 | 1.16 | 1.04–1.29 | |||
| χ2(1, N = 75) = 9.74, p = 0.008 | 0.17–1.22 | ||||||
aMediation analysis conducted using bootstrapped bias-corrected 95% confidence intervals with 5000 bootstrapping samples