Table 3. Results of the most parsimonious models for the groups of studies.
| Group | Mean structure | estimate | se | ci.lb | ci.ub | Pval | |
|---|---|---|---|---|---|---|---|
| Case-Controls | intrcpt | 1.0023 | 0.0129 | 0.9771 | 1.0275 | < .0001 | I2 |
| Region2 | -0.1842 | 0.0065 | -0.197 | -0.1714 | < .0001 | 97.5054 | |
| Region6 | -0.1052 | 0.0074 | -0.1196 | -0.0907 | < .0001 | R2 | |
| Individual type CTR | 0.0566 | 0.0069 | 0.0431 | 0.0701 | < .0001 | 0.5229 | |
| GTC treatment | intrcpt | 0.9924 | 0.032 | 0.9297 | 1.055 | < .0001 | I2 |
| Region2 | -0.1475 | 0.0214 | -0.1893 | -0.1056 | < .0001 | 96.8124 | |
| Region6 | -0.0855 | 0.0295 | -0.1434 | -0.0276 | 0.0038 | R2 | |
| treatment- | 0.0259 | 0.0196 | -0.0124 | 0.0643 | 0.1855 | 0.2623 | |
| Vertebral fractures | intrcpt | 0.9204 | 0.0357 | 0.8504 | 0.9904 | < .0001 | I2 |
| Region2 | -0.1592 | 0.0203 | -0.1989 | -0.1194 | < .0001 | 95.7399 | |
| Region6 | -0.0777 | 0.0152 | -0.1075 | -0.0479 | < .0001 | R2 | |
| FV- | 0.0331 | 0.0137 | 0.0063 | 0.06 | 0.0156 | 0.2621 |
Reference categories for Region, case-control status, treatment status and vertebral fractures status are Region 1, Case, GCT treatment + and FV + respectively. Region1: Lumbar, Region 2: Femoral, Region 6: total hip. Individual type Case: cases, Individual type CTR: controls. GCT treatment+: group under treatment; GCT treatment-: group without treatment. FV+: group with fractures; FV: group without fractures. I2: Heterogeneity by means of Higgins’s tests
Abbreviation: GCT: glucocorticoid; ci.lb: confidence interval lower bound; ci.ub: confidence interval upper bound