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. 2018 Jun 13;13(6):e0198938. doi: 10.1371/journal.pone.0198938

Fig 1. Combined effects of liraglutide and metformin on cell proliferation in human pancreatic cancer cells.

Fig 1

MiaPaca-2 cells were incubated for 48 h with metformin (a) or liraglutide (b) alone or in combination (c) at the specified concentration. Cell viability (top) and cell numbers (middle) for each treatment group were measured using the CCK-8 assay, and the protein level of the cell proliferation marker PCNA was determined by western blot analysis (bottom). Data are shown as means ± SD. n = 4. *P<0.05 vs. control. Lira, liraglutide; Met, metformin; PCNA, proliferating cell nuclear antigen.