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. 2018 Jun 13;13(6):e0197610. doi: 10.1371/journal.pone.0197610

Table 3. Comparison of expression of autophagy markers LC3B and p62 in a primary resected EAC cohort and a subcohort of neo-adjuvant chemotherapy (nCTX) treated EAC cases with paclitaxel containing regimens.

Significance was set to 0.05. Statistically significant p-values are shown in bold.

LC3B dots Treatment Total
Primary Resected nCTX
Low 95 (83.3%) 19 (67.9%) 114 (80.3%)
High 19 (16.7%) 9 (32.1%) 28 (19.7%)
Total 114 28 142
p-value = 0.108
p62 dots Treatment Total
Primary Resected nCTX
Low 95 (83.3%) 9 (32.1%) 104 (73.2%)
High 19 (16.7%) 19 (67.9%) 38 (26.8%)
Total 114 28 142
p-value < 0.001
p62 cytoplasmic Treatment Total
Primary Resected nCTX
Low 86 (75.4%) 12 (42.9%) 98 (69.0%)
High 28 (24.6%) 16 (57.1%) 44 (31.0%)
Total 114 28 142
p-value < 0.001
p62 nuclear Treatment Total
Primary Resected nCTX
Low 58 (50.9%) 16 (57.1%) 74 (52.1%)
High 56 (49.1%) 12 (42.9%) 68 (47.9%)
Total 114 28 142
p-value = 0.674
p62 dots-cyto Treatment Total
Primary Resected nCTX
Low 76 (66.7%) 4 (14.3%) 80 (56.3%)
High 38 (33.3%) 24 (85.7%) 62 (43.7%)
Total 114 28 142
p-value < 0.001
LCB/p62 Treatment Total
Primary Resected nCTX
LL 66 (57.9%) 3 (10.7%) 69 (48.6%)
LH 29 (25.4%) 16 (57.1%) 45 (31.7%)
HL 10 (8.8%) 1 (3.6%) 11 (7.7%)
HH 9 (7.9%) 8 (28.6%) 17 (12.0%)
Total 114 28 142
p-value < 0.001