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. Author manuscript; available in PMC: 2019 Jun 1.
Published in final edited form as: Clin Cancer Res. 2018 Feb 23;24(11):2493–2504. doi: 10.1158/1078-0432.CCR-17-3322

Figure 4. High-dose TGFβ blockade combined with radiation reduces regulatory networks within the myeloid compartment while boosting Tregs.

Figure 4

A) Data are % of CD4 cells that highly express CD25 while being low or negative for CD127 as individual points or B) as log2 fold change to individual’s baseline values. C) Individual log2 fold changes in CD4+ Tregs side-by-side survivinreactive CD8+ T cells changes in patients ranked according to increasing survival within each treatment arm. D) Myeloid cells with the monocytic (CD14+DR-CD16-) or E) the granulocytic (CD15+DR-CD14-CD11b+) myeloid-derived suppressor cell profile are shown as relative change over time to individual’s baseline values. (N=treated at NYU; U=treated at UCLA; black=1mg and red=10mg fresolimumab, green=11 healthy volunteers)