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. Author manuscript; available in PMC: 2018 Jun 13.
Published in final edited form as: Mol Pharm. 2018 Feb 2;15(3):1309–1318. doi: 10.1021/acs.molpharmaceut.7b01114

Figure 4.

Figure 4

Histological Toxicity Comparison of unloaded Ace-DEX and Ace-DEX/10DXR Scaffolds. Coronal sections of mice euthanized 14 days after scaffold implantation with Left) Unloaded acetalated dextran (Ace-DEX) scaffold (total scaffold mass of 2.2 mg) and Right) 10% w/w Ace-DEX/10DXR scaffold (total scaffold mass of 2.2 mg) with total amount of doxorubicin (DXR) equal to 200 μg. Images show sections stained with hematoxylin and eosin (H&E), glial fibrillary acidic protein (GFAP, indicating glial reaction), CD45, (immune cell infiltrates), and F4/80 (macrophages). Scale bars are the equivalent for all images at the same magnification. Black boxes indicate location of magnified region of interest presented in subsequent column.