Fig. 1.

Treadmill exercise reduces the amount of β-amyloid (Aβ) plaque deposition in the hippocampus of APP/PSI transgenic mice. (a) Immunohistochemistry images showing Aβ plaque deposition; (b) quantitative analysis of Aβ deposition. N=6 for each group. **Aβ area was statistically different between WT-SED and TG-SED (P<0.01); ^##Aβ area was statistically different between TG-SED and TG-EXE (P<0.01). TG-EXE, transgenic exercise; TG-SED, transgenic sedentary; WT-EXE, wild-type exercise; WT-SED, wild-type sedentary.