Fig. 1.

Results of the dose–response relationship of isosteviol sodium (STVNa) were measured 3 and 7 days after traumatic brain injury (TBI) in rats. (a) The distribution of percent area of infarct in serial brain sections stained with cresyl violet-stain 3 days after TBI in vehicle-treated and STVNa-treated rats. (b) Neurological scores of Modified Neurological Severity Score (mNSS) 3 days after TBI in the study of the dose–response relationship of STVNa. (c) Neurological scores of mNSS at 3 and 7 days after TBI. (d) Neurological scores of the Bederson test at 3 and 7 days after TBI. Data were expressed as the mean±SEM (n=8/group). *P<0.05, **P<0.01 and ***P<0.001 versus the vehicle group by one-way analysis of variance with Tukey’s multiple-comparison test.