. Author manuscript; available in PMC: 2018 Jun 13.

Published in final edited form as: J Med Chem. 2017 Nov 13;60(22):9320–9329. doi: 10.1021/acs.jmedchem.7b01295

Table 3.

Molecular Interactions between [Leu³, Leu⁷, Phe⁸]-γ-MSH-NH₂ and hMC1R

interacting residue on 5	interacting residue on hMC1R	distance, Å	type of interaction
His5 NE2	Thr262	1.14	H-bond
His5	His260	5.12	π–π stacking
Phe6	Trp254	3.68	π–π stacking
Phe6	Phe257	3.16	π–π stacking
Tyr1	Phe277	5.32	π–π stacking
Tyr1	Phe280	3.99	π–π stacking
Leu7 N	Cys125	2.79	H-bond
Asp9 OD1	Ser126	2.62	H-bond
Arg10 NH2	Asp117	1.79	salt bridge
Phe11	Phe45	3.55	π–π stacking