. Author manuscript; available in PMC: 2018 Jun 13.

Published in final edited form as: J Med Chem. 2017 Nov 13;60(22):9320–9329. doi: 10.1021/acs.jmedchem.7b01295

Table 4.

Molecular Interactions between Compound 1 and hMC1R

interacting residue on 1	interacting residue on hMC1R	distance, Å	type of interaction
His N	Ile276	2.30	H-bond
Arg NE	Glu94	1.93	H-bond
Arg NH2	Glu94	2.27	H-bond
Arg NH2	Thr124	2.31	H-bond
Arg NH1	Asp121	2.72	H-bond
Trp	Phe179	5.02	π–π stacking
Trp N	Asp121	1.90	H-bond