Figure 1.

Experimental timeline for male and female mice differentially subjected to ongoing life stress (A) or control unstressed mice (B) before SNI. Baseline sensitivity tests were measured before SNI and anxiety tests were performed before and after SNI within the time frames shown. A separate group of animals were used for plasma blood draws and these assays were measured between 4 and 5 weeks after SNI and within the same time frame for control and ongoing life-stress animals. SNI, spared nerve injury.