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. 2018 May 24;3(3):e651. doi: 10.1097/PR9.0000000000000651

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Copyright © 2018 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The International Association for the Study of Pain.

This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Plasma corticosterone levels in unrestrained (A) and restrained (B) male and female, control and stressed mice before and after SNI (each group contained n = 6–10 mice). (A) Within the unrestrained group, repeated-measures ANOVA demonstrates a main effect for SNI (P < 0.01) and for Stress (P < 0.05) with a significant difference between these groups (P < 0.05). (B) Within the restrained group, repeated-measures ANOVA demonstrates a main effect of SNI (P < 0.001) and for stress (P < 0.005). Post-hoc analysis demonstrates that a significant effect of sex (P < 0.01) was revealed in naive and post-SNI mice, with higher levels of plasma corticosterone in males relative to females. Error SEM. ANOVA, analysis of variance; SNI, spared nerve injury.