Results of glucose (A), insulin (B), ISR (C), C-peptide (D), and glucagon (F) measured during the 6-h MMCT following the period of caloric restriction alone (left column) vs identical caloric restriction alongside with RYGB (right column); open circles (○) indicates day 2 in the Diet only Period, filled circles (●) indicates day 10 in Diet only Period, open squares (□) indicates day 2 in Diet and RYGB Period, filled squares (■) indicates day 10 in Diet and RYGB Period. Plotted values are presented as mean ± SD
ISR – total insulin secretion rate, MMCT – mixed-meal challenge test, RYGB - Roux-en-Y gastric bypass