Table 2.
Median and range of selected polychlorinated biphenyl (PCB) and organochlorine (OC) pesticide analytes by thyroid cancer status, and odds ratios (OR) and 95% confidence intervals (95%CI) for thyroid cancer reflecting a 10, 100, or 1000 ng/g change in analyte.
| Thyroid Cancer | Control | |||||
|---|---|---|---|---|---|---|
|
| ||||||
| N | Analyte (ng/g lipid) Median (Range) |
N | Analyte (ng/g lipid) Median (Range) |
p1 | OR (95% CI) | |
| Total PCBs2 | 102 | 971.4 (278.2–3977.8) | 205 | 1075 (199.9–4240.8) | 0.10 | 0.96 (0.90–1.02) |
| Low-chlorinated2 | 107 | 67.8 (13.9–673.2) | 215 | 69.9 (15.8–1262.1) | 0.61 | 0.98 (0.76–1.26) |
| PCB 282 | 108 | 19.8 (3.2–468) | 216 | 19.7 (3.8–679) | 0.83 | 1.05 (0.70–1.58) |
| PCB 743 | 108 | 21 (5.8–92) | 216 | 23.5 (1.2–94.3) | 0.09 | 0.85 (0.69–1.05) |
| Moderately-chlorinated2 | 104 | 806.4 (230.1–3597.3) | 206 | 919.9 (161.8–3900.7) | 0.13 | 0.95 (0.88–1.02) |
| PCB 993 | 108 | 30.6 (3–120) | 216 | 33.1 (5.4–162) | 0.08 | 0.85 (0.72–1.00) |
| PCB 1053 | 108 | 15 (0.4–57.5) | 216 | 16 (0.7–65.7) | 0.34 | 0.83 (0.62–1.12) |
| PCB 1183 | 108 | 61.3 (13.2–226) | 216 | 68.7 (14.9–288) | 0.30 | 0.96 (0.89–1.04) |
| PCB 138/1582 | 108 | 168 (36.1–689) | 216 | 188.5 (31.7–827) | 0.28 | 0.86 (0.64–1.15) |
| PCB 1463 | 108 | 25.6 (8.8–152) | 216 | 28.9 (4.7–169) | 0.29 | 0.94 (0.80–1.11) |
| PCB 1532 | 108 | 197.5 (41.2–928) | 216 | 222 (38.7–1120) | 0.24 | 0.91 (0.72–1.14) |
| PCB 1563 | 108 | 19.6 (7.3–96.1) | 216 | 21.4 (4.2–84.6) | 0.16 | 0.90 (0.71–1.13) |
| PCB 1703 | 108 | 51.6 (22.6–217) | 216 | 56.9 (11.4–214) | 0.18 | 0.96 (0.87–1.05) |
| PCB 1802 | 108 | 112.5 (48.9–570) | 216 | 127 (23.5–513) | 0.20k | 0.86 (0.58–1.27) |
| PCB 1833 | 108 | 18.2 (2.7–64.8) | 216 | 20.2 (3.7–77.2) | 0.30 | 0.85 (0.64–1.14) |
| PCB 1873 | 108 | 39.8 (10.4–204) | 216 | 44.2 (5.9–186) | 0.17 | 0.94 (0.84–1.06) |
| Highly-chlorinated3 | 107 | 65.6 (27.4–269.5) | 216 | 71.5 (10.4–274.7) | 0.06 | 0.95 (0.88–1.02) |
| PCB 1943 | 108 | 15.5 (6.2–68.1) | 216 | 16.5 (0.5–75.9) | 0.18 | 0.88 (0.67–1.15) |
| PCB 196/2033 | 108 | 17.9 (6.2–74.5) | 216 | 19.7 (3.4–69.9) | 0.08 | 0.79 (0.59–1.04) |
| PCB 1993 | 108 | 16.6 (6.3–67) | 216 | 17.9 (2.3–77.6) | 0.06 | 0.77 (0.58–1.03) |
| Thyroid-like2 | 103 | 179.4 (35.6–945.7) | 205 | 191.0 (44.6–1064.4) | 0.33 | 0.90 (0.69–1.16) |
| Dioxin-like3 | 104 | 113.1 (36.0–452.5) | 206 | 127.0 (28.7–505.8) | 0.16 | 0.97 (0.92–1.01) |
| Wolff 1A3 | 107 | 13.3 (1.8–187.8) | 215 | 13.4 (2.4–423) | 0.84 | 0.98 (0.91–1.06) |
| Wolff 1B3 | 108 | 59.9 (15.1–265.1) | 216 | 68.1 (8.9–241.9) | 0.13 | 0.94 (0.86–1.03) |
| Wolff 2A2 | 108 | 134.3 (39.1–524.7) | 216 | 152.8 (34.2–592.1) | 0.15 | 0.80 (0.55–1.16) |
| Wolff 2B2 | 108 | 224.3 (59.9–915.6) | 216 | 247.1 (43.8–1069.8) | 0.24 | 0.89 (0.71–1.11) |
| Wolff 32 | 108 | 364.3 (102.8–1675.2) | 216 | 403.3 (71–1857.7) | 0.17 | 0.94 (0.82–1.07) |
| OC Insecticides | ||||||
| DDT Metabolites4 | 104 | 1630.3 (93–6793.6) | 209 | 1845.5 (145–11511.4) | 0.09 | 0.80 (0.66–0.98) |
| p,p′-DDE4 | 104 | 1445 (67.6–6000) | 209 | 1630 (123–10800) | 0.08 | 0.79 (0.64–0.97) |
| p,p >-DDT2 | 108 | 166.5 (12.5–762) | 216 | 198 (10.8–1450) | 0.18 | 0.86 (0.71–1.05) |
| O,p′-DDT3 | 108 | 11 (2–75.3) | 216 | 13.3 (2.1–115) | 0.13 | 0.81 (0.64–1.02) |
| Chlordane Metabolites3 | 108 | 28.4 (4.1–134.9) | 215 | 31.1 (6.5–168.6) | 0.32 | 0.92 (0.80–1.06) |
| trans-nonachlor3 | 108 | 16.8 (2.1–86.7) | 216 | 18.8 (3.7–97) | 0.44 | 0.89 (0.71–1.11) |
| β-HCCH2 | 106 | 65.5 (1.8–452) | 214 | 74.2 (2.5–3320) | 0.06 | 0.62 (0.33–1.16) |
| HCB2 | 106 | 173 (27.7–667) | 214 | 194 (11.1–2250) | 0.10 | 0.76 (0.54–1.06) |
Abbreviations: dichlorodiphenyldichloroethylene (DDE), dichlorodiphenyltrichloroethane (DDT), hexachlorocyclohexane (HCCH), hexachlorobenzene (HCB)
1
Wilcoxon rank sum test
2
OR reflects 100-unit change
3
OR reflects 10-unit change
4
OR reflects 1000-unit change