Table 4.
Univariate and multivariate logistic regression analysis for grade 4 lymphopenia in propensity score matched cohort (N = 272).
| Characteristic | Univariate | Multivariable | ||
|---|---|---|---|---|
|
| ||||
| OR (95% CI) | P value | OR (95% CI) | P value | |
| Age | 1.032 (1.003–1.061) | 0.03 | 1.038 (1.007–1.069) | 0.02 |
| PTV (per cc increase) | 1.001 (1.000–1.002) | 0.08 | 1.000 (1.000–1.002) | 0.09 |
| Gender | ||||
| Female | 1.000 | |||
| Male | 0.755 (0.345–1.649) | 0.48 | ||
| Stage | ||||
| I–IIB | 1.000 | |||
| III–IVA | 1.049 (0.610–1.803) | 0.86 | ||
| KPS | ||||
| 70 | 1.000 | |||
| 80–100 | 0.674 (0.157–2.889) | 0.59 | ||
| Tumor location | ||||
| Upper-middle | 1.000 | |||
| Lower | 1.663 (0.345–8.009) | 0.53 | ||
| Induction chemotherapy | ||||
| No | 1.000 | |||
| Yes | 1.215 (0.708–2.085) | 0.48 | ||
| Histology | ||||
| Adenocarcinoma | 1.000 | |||
| SCC | 0.977 (0.186–5.143) | 0.98 | ||
| RT Modality | ||||
| IMRT | 1.000 | 1.000 | ||
| PBT | 0.316 (0.181–0.552) | 0.0001 | 0.290 (0.164–0.515) | <0.0001 |
Abbreviations: OR = odds ratio, CI = confidence interval, PTV = planning target volume, KPS = Karnofsky performance status, SCC = Squamous cell carcinoma, RT = radiation therapy, IMRT = intensity-modulated radiation therapy, PBT = proton beam therapy.