Table 2.
Study population characteristics for participants at Entry (Baseline) and in Year 2 and Year 7
| Characteristic | BOYS | GIRLS | ||||
|---|---|---|---|---|---|---|
|
| ||||||
| ENTRY | YEAR 2 | YEAR 7 | ENTRY | YEAR 2 | YEAR 7 | |
|
| ||||||
| Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | |
|
| ||||||
| Age | 10.17 (.82) | 12.22 (.84) | 17.15 (.85) | 10.14 (.93) | 12.15 (.96) | 17.06 (1.03) |
|
| ||||||
| School Year | 4.05 (1.05) | 5.78 (1.21) | 9.40 (2.05) | 4.14 (1.07) | 5.91 (1.16) | 9.86 (1.51) |
|
| ||||||
| Non-Verbal IQ (at entry only) | 85.96 (9.96) | — | — | 85.54 (10.23) | — | — |
|
| ||||||
| Blood Lead Concentrations (BPb) |
||||||
|
| ||||||
| BPb Mean μg/dl (SD) | 5.26(2.73) | — | — | 4.42(2.19) | — | — |
| Calculated lnBPb Mean (SD) | 2.53(0.50) | — | — | 2.37(0.48) | — | — |
|
| ||||||
| Distribution | % (N) | % (N) | % (N) | % (N) | % (N) | % (N) |
|
| ||||||
| Total Subjects (N) | 163 | 158 | 120 | 167 | 151 | 119 |
|
| ||||||
| Caucasian - % (N) | 74.2% (121) | 74.2% (118) | 71.7% (86) | 71.3% (119) | 69.1% (105) | 69.7% (83) |
|
| ||||||
| GRIN2A - rs727605 | ||||||
| MAF=37% | ||||||
| Major (CC) | 36% (59) | 36% (57) | 35% (42) | 45% (75) | 45% (68) | 45% (54) |
| Minor Heterozygous (CT) | 49% (80) | 49% (77) | 51% (61) | 42% (70 %) | 41% (62) | 40% (48) |
| Minor Homozygous (TT) | 15% (24) | 15% (24) | 14% (17) | 13% (22) | 14% (21) | 14% (17) |
|
| ||||||
| GRIN2A - rs1070503 | ||||||
| MAF=16% | ||||||
| Major (CC) | 71% (116) | 72% (114) | 68% (82) | 69% (116) | 68% (103) | 69% (82) |
| Minor Heterozygous (CT) | 26% (43) | 25% (40) | 29% (35) | 28% (46) | 28% (43) | 28% (33) |
| Minor Homozygous (TT) | 3% (4) | 3% (4) | 3% (3) | 3% (5) | 3% (5) | 3% (4) |
|
| ||||||
| GRIN2B - rs7301328 | ||||||
| MAF=42% | ||||||
| Major (CC) | 35% (56) | 34% (54) | 34% (41) | 35% (58) | 34% (51) | 34% (40) |
| Minor Heterozygous (CG) | 50% (82) | 51% (80) | 50% (60) | 20% (34) | 45% (68) | 46% (55) |
| Minor Homozygous (GG) | 15% (25) | 15% (24) | 16% (19) | 45% (75) | 21% (32) | 20% (24) |
|
| ||||||
| GRIN2B - rs1806201 | ||||||
| MAF=22% | ||||||
| Major (CC) | 59% (96) | 60% (95) | 64% (77) | 66% (110) | 66% (99) | 69% (82) |
| Minor Heterozygous (CT) | 35% (57) | 34% (54) | 31% (37) | 29% (49) | 30% (45) | 26% (31) |
| Minor Homozygous (TT) | 6% (10) | 6% (9) | 5% (6) | 5% (8) | 5% (7) | 5% (6) |
MAF: Minor Allelic Frequency