Table 3.
Dose-response Effects of Lead on Neurobehavioral Test Performance after 7 years among BOYS and GIRLS with Minor (CT/TT) Genotype Status in either GRIN2A polymorphism
| GRIN2A rs727605 Minor (CT/TT) | GRIN2A rs1070503 Minor (CT/TT) | ||||
|---|---|---|---|---|---|
| Behavioral Test | Domain | Boys | Girls | Boys | Girls |
| Beta (Cred. Int.) | Beta (Cred. Int.) | Beta (Cred. Int.) | Beta (Cred. Int.) | ||
| srtmean | Vis-Sp | −0.01 (−0.020, − 0.002) | −0.01 (−0.022, −0.002) | 0.00 (−0.013, 0.008) | −0.01 (−0.027, −0.001) |
| Ravlt Tr1 | L&M | −0.14 (−0.263, − 0.029) | −0.03 (−0.158, 0.087) | −0.17 (−0.314, −0.038) | −0.10 (−0.270, 0.076) |
| Ravlt Tr5 | L&M | −0.16 (−0.262, − 0.046) | −0.10 (−0.221, 0.009) | −0.15 (−0.271, −0.021) | −0.12 (−0.277, 0.050) |
| Ravlt Tr6 | L&M | −0.13 (−0.257, − 0.015) | −0.02 (−0.146, 0.114) | −0.13 (−0.281, 0.004) | −0.05 (−0.239, 0.122) |
| Ravlt Tr7 | L&M | −0.17 (−0.291, − 0.057) | −0.08 (−0.209, 0.032) | −0.19 (−0.329, −0.060) | −0.09 (−0.261, 0.078) |
| Ravlt Tr8 | L&M | −0.19 (−0.329, − 0.067) | −0.05 (−0.175, 0.077) | −0.25 (−0.392, −0.105) | −0.06 (−0.231, 0.121) |
| Ravlttot | L&M | −0.29 (−0.945, − 0.035) | −0.06 (−0.321, 0.214) | −0.37 (−0.746, −0.069) | −0.07 (−0.417, 0.266) |
| vireim | L&M | −0.18 (−0.410, − 0.010) | −0.01 (−0181, 0.216) | −0.27 (−0.493, −0.064) | 0.04 (−0.213, 0.322) |
| Virede | L&M | −0.18 (−0.431, − 0.005) | −0.02 (−0.209, 0.215) | −0.31 (−0.558, −0.074) | 0.06 (−0.201, 0.352) |
| wcscatcp | Exec Fn | −0.07 (−0.133, 0.005) | −0.03 (−0.106, 0.053) | −0.10 (−0.186, −0.017) | −0.12 (−0.239, −0.023) |
| wcscorr | Exec Fn | −0.13 (−0.512, 0.061) | −0.03 (−0.297, 0.231) | −0.29 (−0.640, −0.010) | −0.17 (−0.630, 0.182) |
Data are presented as Betas, their 95% credible intervals (Cred. Int.). Values in bold exclude the null effect at the 95% credible interval. Note that each GRIN2A polymorphism is modelled independently.