Table 5.
Dose-response Effects of Lead on Neurobehavioral Test Performance among Year 7 BOYS carrying Minor alleles for both GRIN2A polymorphisms or both GRIN2B polymorphisms.
| GRIN2A (1 or 2 × CT/TT) | GRIN2B ((1 or 2 × CT/TT + 1 or 2 × CG/GG)) | ||||
|---|---|---|---|---|---|
| Behavioral Test | Domain | Boys | Girls | Boys | Girls |
| Beta (Cred. Int.) | Beta (Cred. Int.) | Beta (Cred. Int.) | Beta (Cred. Int.) | ||
| srtmean | Vis-Sp | −0.01 (−0.016, 0.002) | −0.01 (−0.022, − 0.002) | −0.01 (−0.021, −0.002) | −0.01 (− 0.023, − 0.003) |
| Ravlt Tr1 | L&M | −0.14 (−0.255, − 0.028) | −0.05 (−0.166, 0.072) | −0.13 (−0.251, −0.003) | −0.07 (−0.202, 0.060) |
| Ravlt Tr5 | L&M | −0.14 (−0.242, − 0.031) | −0.08 (−0.200, 0.027) | −0.16 (−0.273, −0.044) | −0.13 (− 0.254, − 0.012) |
| Ravlt Tr6 | L&M | −0.14 (−0.257, − 0.018) | −0.03 (−0.149, 0.095) | −0.11 (−0.237, 0.021) | −0.00 (−0.140, 0.136) |
| Ravlt Tr7 | L&M | −0.16 (−0.274, − 0.052) | −0.07 (−0.195, 0.038) | −0.16 (−0.282, −0.038) | −0.12 (−0.247, 0.009) |
| Ravlt Tr8 | L&M | −0.20 (−0.315, − 0.081) | −0.04 (−0.167, 0.073) | −0.24 (−0.372, −0.112) | −0.13 (−0.262, 0.011) |
| Ravlttot | L&M | −0.43 (−0.749, − 0.106) | −0.05 (−0.288, 0.162) | −0.47 (−0.823, −0.155) | −0.19 (−0.511, 0.085) |
| vireim | L&M | −0.25 (−0.456, − 0.072) | −0.02 (−0.185, 0.178) | −0.34 (−0.547, −0.132) | 0.00 (−0.207, 0.218) |
| Virede | L&M | −0.27 (−0.487, − 0.073) | −0.03 (−0.194, 0.186) | −0.39 (−0.614, −0.152) | −0.03 (−0.253, 0.201) |
| wcscatcp | Exec Fn | −0.07 (−0.148, 0.010) | −0.05 (−0.130, 0.029) | −0.10 (−0.176, −0.022) | −0.08 (− 0.164, − 0.008) |
| wcscorr | Exec Fn | −0.23 (−0.530, 0.051) | −0.05 (−0.297, 0.182) | −0.37 (−0.713, −0.058) | −0.20 (−0.539, 0.104) |
Data are presented as Betas, their 95% credible intervals (Cred. Int.). Values in bold exclude the null effect at the 95% credible interval. Note that each GRIN2B polymorphism is modelled independently.