Table 1.
Comparison of metabolic characteristics and renal parameters in patients with generalized lipodystrophy and familial partial lipodystrophy.
| Generalized lipodystrophy (n = 37) | Familial partial lipodystrophy (n = 44) | p value | |
|---|---|---|---|
| Age (years) | 21 ± 17 | 38 ± 15 | < 0.001 |
| Gender (F/M) | 21/16 | 35/9 | 0.032 |
| BMI (kg/m2) | 19.05 ± 3.25 | 23.73 ± 4.87 | 0.003 |
| Follow-up (months) | 72 ± 56 | 57 ± 84 | 0.001 |
| Diabetes/ IGT | 20 (54%)/ 3 (8%) | 31 (71%)/ 4 (9%) | 0.221 |
| Duration of diabetes (months) | 151 ± 97 | 127 ± 102 | 0.403 |
| Hypertension | 8 (22%) | 17 (39%) | 0.147 |
| Glucose (mmol/L) | 8.01 ± 4.39 | 8.18 ± 3.41 | 0.851 |
| HbA1c (%) | 7.63 ± 2.66 | 7.38 ± 1.94 | 0.629 |
| HOMA-IR score | 19.78 ± 25.21 | 9.88 ± 9.32 | 0.025 |
| ALT (IU/L) | 56 ± 55 | 31 ± 24 | 0.048 |
| GGT (IU/L) | 69 ± 72 | 53 ± 59 | 0.288 |
| Total cholesterol (mmol/L) | 5 ± 2.43 | 5.66 ± 1.98 | 0.023 |
| LDL cholesterol (mmol/L) | 2.34 ± 1.13 | 2.94 ± 1.14 | 0.084 |
| HDL cholesterol (mmol/L) | 0.69 ± 0.26 | 0.89 ± 0.28 | 0.069 |
| Triglyceride (mmol/L) | 7.78 ± 9.42 | 5.86 ± 5.54 | 0.258 |
| Leptin (ng/mL) | 0.69 ± 0.81 | 6.47 ± 6.54 | < 0.001 |
| Adiponectin (μg/mL) | 5.33 ± 7.98 | 9.01 ± 7.73 | 0.033 |
| Creatinine (mg/dL) | 1.1 ± 1.5 | 0.67 ± 0.21 | 0.067 |
| C3 (mg/dL) | 137 ± 28 | 142 ± 24 | 0.469 |
| CKD | 17 (46 %) | 23 (52 %) | 0.657 |
| eGFR (ml/min/1.73 m2) | 101 ± 48 | 109 ± 23 | 0.302 |
| Urinary protein excretion (mg/day) | 1061 ± 2982 | 349 ± 1084 | 0.15 |
| The median age when CKD was first detected | 23 ± 14 | 41 ±13 | 0.007 |
| Macroalbuminuria (severely increased albuminuria) | 13 (35%) | 9 (21%) | 0.21 |
| Nephrotic range proteinuria | 5 (14 %) | 2 (5 %) | 0.237 |
| eGFR < 60 ml/min/1.73 m2 | 8 (22 %) | 3 (7 %) | 0.1 |
| ESRD, eGFR < 15 ml/min/1.73 m2 | 4 (11 %) | None | 0.04 |
ALT: Alanine aminotransferase, BMI: Body mass index, CKD: Chronic kidney disease, C3: Complement-3, eGFR: Estimated glomerular filtration rate, ESRD: end stage renal disease, F: Female, GGT: Gamma-glutamyl transferase, HOMA-IR: Homeostatic model assessment, HDL: High density lipoprotein, IGT: Impaired glucose tolerance, LDL: Low density lipoprotein, M: Male. Data are presented as mean ± standard deviation (SD). Laboratory data shown are collected at the time of final visit.