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. Author manuscript; available in PMC: 2019 Jun 13.
Published in final edited form as: J Am Chem Soc. 2018 Jun 4;140(23):7116–7126. doi: 10.1021/jacs.8b01933

Figure 3.

Figure 3

Positive-mode single-ion LC-MS chromatograms showing that NapI can hydroxylate but not desaturate the 6-deaza analogue of L-Arg, L-indospicine. The front three traces are from a control lacking the co-substrate, 2OG. The middle traces are from analysis of a reaction carried out under atmospheric O2. The rear traces are from a reaction under 18O2. Coloring coding of the traces is: black, m/z = 174 (indospicine); green, m/z = 190 (H16O-indospicine); gray, m/z = 192 (H18O-indospicine); blue, m/z = 172 (dehydroindospicine; not observed).