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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: Biomaterials. 2018 May 26;176:71–83. doi: 10.1016/j.biomaterials.2018.05.041

Fig. 4. Intravenous injection of the THR and scAAV8-CBh-eGFP complex leads to neuron cell transduction in the brain.

Fig. 4

Fig. 4

Fig. 4

2×1011 vg of either scAAV8-CBh-eGFP or scAAV8-eGFP-0.4 mM THR was retro-orbitally injected into the mice (n = 3). Representative images of the EGFP expression (green) of AAV8 was colocalized with CD31 (red, endothelial marker) in the cortex (A), GFAP (red, astrocyte marker) in the cortex (B), and NeuN (red, neuronal marker) in the hippocampal CA1 region (C) in the mice brain, and were merged with DAPI (blue), were captured and assessed after 4 weeks. Scale bars, 50 μm (Objective 20× optical axis).