1.

患者基线资料

Baseline of the patients

	Intervention group	Control group	P value
COPD: chronic obstructive pulmonary disease; FEV1: forced expiratory volume in one second; FVC: forced vital capacity; MVV: maximum ventilatory volume; Dlco SB: diffusion capacity for carbon monoxide of the lung (single breath).
Age	63.13±6.26	64.04±8.94	0.683
Gender			0.763
Female	9 (37.5%)	11 (45.8%)
Male	15 (62.5%)	13 (54.2%)
Lung function
FVC (L)	2.90±0.87	2.74±0.77	0.507
FEV1	2.42±0.79	2.51±0.74	0.443
MVV	93.42±27.49	87.69±26.79	0.220
Dlco SB	22.62±4.28	21.83±4.35	0.881
COPD classification			0.525
Mild	6 (25.0%)	8 (33.3%)
Moderate	18 (75.0%)	16 (66.7%)
Smoking status			0.461
Current-smoker	7 (29.2%)	7 (29.2%)
Non-smoker	11 (45.8%)	13 (54.2%)
Ever-smoker	6 (25.0%)	4 (16.6%)
Pathological stage			0.366
Stage 0 or Ⅰ	8 (33.3%)	13 (54.2%)
Stage Ⅱ	13 (54.2%)	8 (33.3%)
Stage Ⅲ	2 (8.3%)	3 (12.5%)
Stage Ⅳ	1 (4.2%)	0 (0)
Tumor pathological type			0.955
Adenocarcinoma	11 (45.8%)	10 (41.7%)
Squamous carcinoma	11 (45.8%)	12 (50.0%)
Adenosquamous carcinoma	2 (8.3%)	2 (8.3%)
Tumor grade			0.318
Poorly differentiated	13 (54.1%)	10 (41.7%)
Between moderate and poor	6 (25.0%)	6 (25.0%)
Moderate differentiated	4 (16.7%)	2 (8.3%)
Between moderate and high	1 (4.2%)	5 (20.8%)
High-differentiated	0 (0)	1 (4.2%)