3.
3p区抑癌基因甲基化与非小细胞肺癌患者临床病理特征的关系
Association between the DNA methylation in NSCLC specimens and clinicopathological features
| Characteristic | n | Methylation frequency [n (%)] | Mean MI | |||
| DLEC1 | RASSF1A | RARβ | hMLH1 | |||
| *P < 0.05 | ||||||
| Gender | ||||||
| Male | 58 | 22 (37.93) | 24 (41.38) | 16 (27.59) | 9 (15.52) | 0.306±0.116 |
| Female | 20 | 10 (50.00) | 7 (35.00) | 8 (40.00) | 4 (20.00) | 0.363±0.125 |
| Age (year) | ||||||
| < 60 | 22 | 8 (36.36) | 6 (27.27) | 5 (22.76) | 3 (13.64) | 0.341±0.095 |
| ≥60 | 56 | 24 (42.86) | 25 (44.64) | 19 (33.93) | 10 (17.86) | 0.348±0.122 |
| Histological type | ||||||
| Adenocarcinoma | 30 | 12 (40.0) | 14 (46.67) | 8 (26.67) | 4 (13.33) | 0.317±0.148 |
| Squamous cell carcinoma | 36 | 16 (44.44) | 12 (33.33) | 14 (38.89) | 8 (22.22) | 0.347±0.095 |
| Others | 12 | 4 (33.33) | 5 (41.67) | 2 (16.67) | 1 (8.33) | 0.250±0.152 |
| Tumor size | ||||||
| ≤3 cm | 25 | 9 (36.0) | 11 (44.0) | 5 (20.0) | 3 (12.0) | 0.280±0.146 |
| >3 cm | 53 | 23 (43.40) | 20 (37.74) | 19 (35.85) | 10 (18.87) | 0.349±0.106 |
| Cellular differentiation | ||||||
| Well | 13 | 4 (30.78) | 6 (46.16) | 3 (23.08) | 2 (15.38) | 0.288±0.131 |
| Moderate | 46 | 17 (36.95) | 18 (39.13) | 15 (32.61) | 7 (15.21) | 0.310±0.108 |
| Poor | 19 | 11 (57.89) | 8 (42.11) | 6 (31.58) | 4 (21.05) | 0.382±0.157 |
| Stage | ||||||
| Ⅰ/Ⅱ | 58 | 19 (32.76) | 22 (37.93) | 18 (31.03) | 8 (13.79) | 0.289±0.105 |
| Ⅲ/Ⅳ | 20 | 13 (65.00)* | 9 (45.00) | 6 (30.00) | 5 (25.00) | 0.412±0.179 |
| Lymph metastasis | ||||||
| N0 | 44 | 13 (29.55) | 17 (38.64) | 12 (27.27) | 7 (15.90) | 0.278±0.093 |
| N1/N2 /N3 | 34 | 19 (55.88)* | 14 (41.18) | 12 (35.29) | 6 (17.64) | 0.375±0.158 |
| Smoking habit | ||||||
| Smoker | 49 | 18 (36.73) | 20 (40.82) | 17 (34.69) | 7 (14.28) | 0.316±0.118 |
| Never | 29 | 14 (48.28) | 11 (37.93) | 7 (24.14) | 6 (20.69) | 0.328±0.127 |