3.

Univariate and multivariate analyses for progression-free survival

Characteristic	PFS (months)	Univariate analysis	Multivariate analysis
		P	Odds ratio (95%CI)
All patients	3.60
Age		0.187	0.315 (0.057-1.751)
≥70 years	3.10
< 70 years	3.79
Gender		0.300	2.111 (0.511-8.664)
Male	3.12
Female	4.62
Perfomance status		0.059	0.237 (0.053-1.058)
2	4.21
≥3	2.22
Histology		0.018	0.178 (0.043-0.742)
Non-squamous cell carcinoma	4.48
Squamous cell carcinoma	2.44
Best response to first-line therapy		0.242	0.387 (0.79-1.899)
Disease control (PR/SD)	4.02
PD	2.58
No. of prior systemic therapy		0.904	0.897 (0.152-5.291)
1	2.13
≥2	3.96