Figure 7.

Effects of U0126, LMB and roscovitine on astroglial apoptosis in the molecular layer of the dentate gyrus following SE. (A) Representative photos demonstrating TUNEL-positive astrocytes. As compared to vehicle, U0126 exacerbates SE-induced astroglial apoptosis, while LMB and roscovitine do not. Bar = 12.5 μm. (B) Quantification of the fractions of TUNEL-positive astrocytes in total astrocytes within the molecular layer of the dentate gyrus. Open circles indicate each individual value. Horizontal bars indicate mean value. Error bars indicate SEM (*,^#p < 0.05 vs. control and vehicle, respectively; n = 7, respectively).