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. 2018 Jun 7;12:152. doi: 10.3389/fncel.2018.00152

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Copyright © 2018 Kim and Kang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of U0126, LMB and roscovitine on neuronal damage in the CA1 region and the dentate gyrus. (A,B) Representative images for Fluoro-Jade B (FJB) signals in CA1 neurons (A) and DGC (B) Bar = 50 μm. As compared to vehicle, U0126 deteriorates SE-induced neuronal damage in CA1 neurons and DGC, while LMB attenuates neuronal damage only in CA1 neurons. Roscovitine does not affect SE-induced neuronal death in CA1 neurons and DGC. (C,D) Quantification of the number of FJB-positive CA1 neurons (C) and DGC (D) Open circles indicate each individual value. Horizontal bars indicate mean value. Error bars indicate SEM (*,^#p < 0.05 vs. control and vehicle, respectively; n = 7, respectively).